PNC-27(10 VIALS/BOX)

Product Details

PNC-27 10 mg research-grade lyophilized peptide powder supplied in a glass vial. PNC-27 is a synthetic peptide construct typically combining a membrane-penetrating peptide sequence with a p53-derived HDM2/MDM2-binding domain and is studied in oncology-focused research models investigating selective cancer cell targeting and membrane-disruptive mechanisms.

Research Overview

PNC-27 is a synthetic peptide construct designed for oncology research. It typically comprises a membrane-penetrating peptide segment (such as an Antennapedia-derived sequence) linked to a peptide fragment corresponding to the HDM2/MDM2-binding domain of the p53 tumor suppressor protein. In experimental in vitro and in vivo models it is used to investigate how targeting membrane-associated HDM2/MDM2 on cancer cells may influence membrane integrity, p53-related pathways and selective cytotoxic responses under controlled laboratory conditions.

Primary Research Areas

• Targeting membrane-bound HDM2/MDM2: used in studies examining how p53-derived peptide segments interact with HDM2/MDM2 proteins localized at the plasma membrane of cancer cells and how this targeting affects signaling and membrane structure.
• Selective cytotoxicity in cancer models: applied in experimental models exploring differential effects on transformed versus non-transformed cells, with emphasis on mechanisms that may preferentially compromise cancer cell viability in vitro.
• Membrane disruption and cell death pathways: incorporated into research on peptide-induced membrane perturbation, pore formation, necrotic and apoptotic signaling cascades, and associated biomarker changes in cancer cell lines.
• p53-related signaling mechanisms: used as a tool to probe interactions between the p53 pathway, HDM2/MDM2 regulation and downstream transcriptional programs in oncology-focused cell and tissue models.
• Preclinical oncology research models: evaluated in a variety of in vitro and in vivo systems, including pancreatic, breast and hematologic cancer models, to study tumor cell responsiveness, resistance patterns and mechanistic endpoints.

Disclaimer: For laboratory and research purposes only. Not intended for human consumption.

Specifications